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'According to research1 published in 2015, 52 percent of Americans are presently either prediabetic or diabetic. A hallmark symptom of both is insulin and leptin resistance, a situation in which your body can no longer "hear" the signals from these important energy-regulating hormones.
According to Dr. Robert Lustig, when an organ becomes insulin resistant, it manifests as chronic metabolic disease.
For example, when you have insulin resistance of the liver, you end up with type 2 diabetes; insulin resistance of the brain results in Alzheimer's disease; insulin resistance of the kidney leads to chronic renal disease, and so on.'